protein spinster homolog 1 (spinster-like protein 1, HSpin1, SPNS1, SPIN1, PP20300)
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Function
- may be involved in necrotic or autophagic cell death
- interacts with BCL2 & BCL2L1
- may interact with beclin-1 & p53[2]
Structure
- belongs to the major facilitator superfamily, Spinster family
Compartment
- mitochondrial inner membrane
- colocalizes with SDHB
Alternative splicing
named isoforms=4
Comparative biology
- mutations in SPNS1 may disturb development & accelerate senescence in zebrafish[2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9H2V7.html
- ↑ 2.0 2.1 2.2 Sasaki T, Lian S, Qi J et al Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency. PLoS Genet. 2014 Jun 26;10(6):e1004409 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24967584