succinate dehydrogenase iron-sulfur subunit (SDHB)

Function

• nuclear-encoded iron-sulfur subunit of mitochondrial complex 2
• carbohydrate metabolism; tricarboxylic acid cycle

succinate + ubiquinone <--> fumarate + ubiquinol

Cofactor:

• binds 1 2Fe-2S cluster (putative)
• binds 1 3Fe-4S cluster (putative)
• binds 1 4Fe-4S cluster (putative)

Structure

• belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family
• contains 1 2Fe-2S ferredoxin-type domain
• contains 1 4Fe-4S type ferredoxin domain

Compartment

mitochondria inner membrane

Pathology

• defects in SDHB are a cause of pheochromocytoma
• defects in SDHB are the cause of hereditary paraganglioma 4

More general terms

• flavoprotein
• protein subunit

Component of

• succinate dehydrogenase (mitochondrial complex 2)

Database

• UniProt: http://www.uniprot.org/uniprot/P21912.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6390
• OMIM: https://mirror.omim.org/entry/115310
• OMIM: https://mirror.omim.org/entry/171300
• OMIM: https://mirror.omim.org/entry/185470