succinate dehydrogenase (mitochondrial complex 2)

Function

carbohydrate metabolism; tricarboxylic acid cycle

succinate + ubiquinone <--> fumarate + ubiquinol

Structure

• four subunits:
  • succinate dehydrogenase flavoprotein subunit (SDHA)
  • succinate dehydrogenase iron-sulfur subunit (SDHB)
  • cytochrome b560 (SDHC)
  • succinate dehydrogenase complex subunit D (SDHD)

Compartment

mitochondria inner membrane

Pathology

• defects in subunits associated with succinate CoQ reductase deficiency

More general terms

• dehydrogenase
• quinone reductase
• citric acid cycle enzyme
• electron transport enzyme
• multisubunit protein

Additional terms

• citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle
• electron transport
• succinate CoQ reductase deficiency (complex 2 mitochondrial respiratory chain deficiency)