succinate dehydrogenase cytochrome b small subunit (cybS, succinate dehydrogenase complex subunit D, SDHD)

Function

• component of mitochondrial electron transport complex 2 (succinate dehydrogenase) which transfers electrons from succinate to ubiquinone (coenzyme Q)
• carbohydrate metabolism; tricarboxylic acid cycle

Structure

belongs to the CybS family

Compartment

mitochondrial inner membrane

Pathology

• defects in SDHD are a cause of hereditary paraganglioma type 1
• defects in SDHD are a cause of pheochromocytoma
• defects in SDHD are involved in intestinal carcinoid tumor

More general terms

• cytochrome
• mitochondrial membrane protein

Component of

• succinate dehydrogenase (mitochondrial complex 2)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6392
• OMIM: https://mirror.omim.org/entry/114900
• OMIM: https://mirror.omim.org/entry/168000
• OMIM: https://mirror.omim.org/entry/171300
• OMIM: https://mirror.omim.org/entry/602690
• UniProt: http://www.uniprot.org/uniprot/O14521.html