succinate; succinic acid

Biochemistry

• succinate is an intermediate in the citric acid cycle
• it is formed by hydrolysis of succinyl CoA via succinyl-CoA synthetase
  • enzyme: succinyl-CoA synthetase
  • substrates: succinyl-CoA + GDP + H2PO4-
  • products: succinate + coenzyme-A + GTP
• succinate is metabolized to form fumarate via succinate dehydrogenase in a reaction that feeds electrons into the electron transport chain (complex II) through flavin adenine dinucleotide (FADH2)
  • enzyme: succinate dehydrogenase
  • substrates: succinate + flavin adenine dinucleotide
  • products: fumarate + FADH2

* see citric acid cycle for role of succinate in citric acid cycle

More general terms

• dicarboxylate
• bioagent

More specific terms

• adenylosuccinate; succinyladenosine; adenylsuccinic acid
• argininosuccinate
• succinimide
• succinyl coenzyme A
• succinylaminoimidazole carboxamide riboside (SAICAR)

Additional terms

• carnitine biosynthesis
• citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle
• electron transport

Component of

• hydrochlorothiazide/metoprolol/succinate
• calcium ascorbate/calcium threonate/cobalamin/ferrous asparto glycinate/liver stomach concentrate/succinate
• calcium ascorbate/calcium threonate/cobalamin/ferrous asparto glycinate/ferrous fumarate/folic acid/succinate
• acetaminophen/chlorpheniramine/dextromethorphan/doxylamine/succinate

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1110
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=160625
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=160419
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=520904