fumarate

Introduction

An intermediate metabolite in the citric acid cycle & in the urea cycle.

Biochemistry

• fumarate is an intermediate metabolit in the citric acid cycle
  • it is formed from succinate via succinate dehydrogenase
    • enzyme: succinate dehydrogenase
    • substrates: succinate + flavin adenine dinucleotide
    • products: fumarate + FADH2
  • it is metabolized to malate via fumarase
    • enzyme: fumarase
    • substrates: fumarate + H2O
    • product: malate

* see citric acid cycle for role of fumarate in citric acid cycle

More general terms

• dicarboxylate
• alkene; olefin

Additional terms

• citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle
• urea cycle

Component of

• formoterol/fumarate/mometasone
• bisoprolol/fumarate/hydrochlorothiazide
• acetaminophen/clemastine/fumarate/pseudoephedrine

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=164547
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=723