ubiquinone; coenzyme Q (CoQ, CoQ10, MitoQ, ubidecarenone)

From Aaushi
Jump to navigation Jump to search

Introduction

Cofactor in mitochondrial electron transport. It is endogenously synthesized from isopentenyl pyrophosphate, an intermediate in the biosynthesis of cholesterol.

Pharmacology

Coenzyme Q10

Indications

(uses)

Dosage

* may lower systolic BP up to 21 mm Hg & diastolic BP up to 16 mm Hg in patients with hypertension[11]

* GRS11 claims that in combination with 25 lb weight loss, may lower systolic blood pressure >140 - 85 = >55 mm Hg (no supporting data provided)

Adverse effects

Drug interactions

Laboratory

Mechanism of action

More general terms

More specific terms

Additional terms

Component of

References

  1. Ghirlanda et al, J Clin Pharmacol. 33:226, 1993
  2. Mortensen et al Mol Aspects Med 18(suppl):S137, 1997
  3. Folkers et al, Proc Natl Acad Sci USA 87:8931, 1990
  4. Bargossi et al, Int J Clin Lab Res 24:171, 1994
  5. 5.0 5.1 5.2 Prescriber's Letter 9(6):33 2002
  6. 6.0 6.1 6.2 Journal Watch 22(23):176, 2002 Shults CW et al, Arch Neurol 59:1541, 2002
  7. 7.0 7.1 7.2 Use of Ubiquinone (Coenzyme Q10) in Patients Taking Statins Prescriber's Letter 11(4):22 2004 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=200420&pb=PRL (subscription needed) http://www.prescribersletter.com
  8. 8.0 8.1 8.2 8.3 8.4 Uses of Coenzyme Q10 Prescriber's Letter 11(7):41 2004 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=200712&pb=PRL (subscription needed) http://www.prescribersletter.com
  9. 9.0 9.1 Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme q10 on myopathic symptoms in patients treated with statins. Am J Cardiol. 2007 May 15;99(10):1409-12. Epub 2007 Apr 3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17493470
  10. 10.0 10.1 10.2 10.3 10.4 10.5 Prescriber's Letter 17(6): 2010 Uses of Coenzyme Q10 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260607&pb=PRL (subscription needed) http://www.prescribersletter.com
  11. 11.0 11.1 11.2 11.3 11.4 11.5 Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
    Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022
  12. 12.0 12.1 Wyman M1, Leonard M, Morledge T. Coenzyme Q10: a therapy for hypertension and statin-induced myalgia? Cleve Clin J Med. 2010 Jul;77(7):435-42. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20601617
  13. 13.0 13.1 Rossman MJ, Santos-Parker JR, Steward CAC et al Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults. Hypertension. 2018 Apr 16. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29661838

Database