carcinoid (argentaffinoma)

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Etiology

risk factors

Epidemiology

  • uncommon, but most common neuroendocrine tumors in U.S.[8]
  • 2% of lung tumors, with higher percentage in younger patients
  • 0.5% of all newly diagnosed cancers[8]
  • generally occur in the 7th decade of life
  • slight female preponderance
  • blacks are affected more frequently than whites
  • no association with smoking
  • incidence of carcinoid appears to be increasing
    • imaging for screening/diagnosis of other conditions may play a role[8]
  • incidental finding in appendectomy specimens from children[8]

Pathology

Microscopic pathology

(colon & rectum)

Genetics

Clinical manifestations

Laboratory

Diagnostic procedures

as needed

Radiology

Staging

World Health Organization (WHO) assigns nuroendocrine tumors 1 of 3 broad grades on the basis of tumor differentiation[8]:

Complications

Management

prognosis: 5-year survival rates

More general terms

More specific terms

Additional terms

References

  1. Stedman's Medical Dictionary 26th ed, Williams & Wilkins, Baltimore, 1995
  2. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 587
  3. WHO Classification Tumours of the Digestive System. IARC Press 2000
  4. Jump up to: 4.0 4.1 ARUP Consult: Neuroendocrine Tumors of the Gastrointestinal Tract, Lung, and Thymus - Carcinoid Tumors The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/carcinoid-tumors
  5. Jump up to: 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 5.9 Medical Knowledge Self Assessment Program (MKSAP) 16, 17, 18, 19. American College of Physicians, Philadelphia 2012, 2015, 2018, 2021.
  6. Jump up to: 6.0 6.1 6.2 6.3 6.4 Cao C, Yan TD, Kennedy C, Hendel N et al Bronchopulmonary carcinoid tumors: long-term outcomes after resection. Ann Thorac Surg. 2011 Feb;91(2):339-43 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21256263
  7. Moertel CG, Weiland LH, Nagorney DM, Dockerty MB. Carcinoid tumor of the appendix: treatment and prognosis. N Engl J Med. 1987 Dec 31;317(27):1699-701. PMID: https://www.ncbi.nlm.nih.gov/pubmed/3696178
  8. Jump up to: 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 8.14 8.15 8.16 8.17 8.18 8.19 8.20 8.21 8.22 8.23 Ahmad A (slide show) Carcinoid Tumors: Cancers in Slow Motion. Medscape. March 30, 2016 http://reference.medscape.com/features/slideshow/carcinoid-tumors

Patient information

carcinoid patient information

Database