bronchiectasis

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Introduction

Chronic dilation of bronchi or bronchioles as a sequel of inflammatory disease or obstruction.

Etiology

Epidemiology

Pathology

  • most commonly occurs in lower lung fields
  • in most cases 2nd to 4th order bronchi are involved
  • bilateral involvement in 30%
  • ~20% of patients with bronchiectasis have eosinophilic inflammation[20]

Clinical manifestations

Laboratory

* eosinophil count < 100/uL associated with greater disease severity & mortality[20]

* higher eosinophilic counts were associated with shorter time to exacerbations[20]

Diagnostic procedures

Radiology

Complications

Management

More general terms

More specific terms

Additional terms

References

  1. Stedman's Medical Dictionary 26th ed, Williams & Wilkins, Baltimore, 1995
  2. Guide to Physical Examination & History Taking, 4th edition, Bates B, JB Lippincott, Philadelphia, 1987
  3. DeGowin & DeGowin's Diagnostic Examination, 6th edition, RL DeGowin (ed), McGraw Hill, NY 1994, pg 870
  4. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 746-48
  5. 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 Medical Knowledge Self Assessment Program (MKSAP) 11, 14, 17, 18, 19. American College of Physicians, Philadelphia 1998, 2006, 2015, 2018, 2022.
  6. 6.0 6.1 Altenburg J et al. Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis: The BAT randomized controlled trial. JAMA 2013 Mar 27; 309:1251 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23532241
    Serisier DJ et al. Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: The BLESS randomized controlled trial. JAMA 2013 Mar 27; 309:1260 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23532242
  7. Chalmers JD, Smith MP, McHugh BJ et al Short- and long-term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med. 2012 Oct 1;186(7):657-65. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22744718
  8. McShane PJ, Naureckas ET, Tino G, Strek ME. Non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med. 2013 Sep 15;188(6):647-56 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23898922
  9. Pasteur MC, Bilton D, Hill AT et al British Thoracic Society guideline for non-CF bronchiectasis. Thorax. 2010 Jul;65 Suppl 1:i1-58. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20627931
  10. 10.0 10.1 10.2 10.3 10.4 10.5 Aksamit TR et al. Adult patients with bronchiectasis: A first look at the US Bronchiectasis Research Registry. Chest 2017 May; 151:982 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27889361
  11. 11.0 11.1 11.2 11.3 Anello J, Feinberg B, Heinegg J et. al. New Guidelines and Recommendations, October 2017 Medscape. Oct 06, 2017. http://reference.medscape.com/viewarticle/886616_15
  12. 12.0 12.1 12.2 NEJM JWatch Question of the Week. March 27, 2018 https://knowledgeplus.nejm.org/question-of-week/562/
  13. 13.0 13.1 Ebihara T, Sasaki H. Bronchiectasis with Mycobacterium avium Complex Infection. N Engl J Med 2002; 346:1372 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/11986411 Free full text <Internet> http://www.nejm.org/doi/full/10.1056/NEJMicm010899
  14. 14.0 14.1 NEJM Knowledge+ Question of the Week. June 19, 2018 https://knowledgeplus.nejm.org/question-of-week/1699/
  15. Milliron B, Henry TS, Veeraraghavan S, Little BP. Bronchiectasis: Mechanisms and Imaging Clues of Associated Common and Uncommon Diseases. Radiographics. 2015 Jul-Aug;35(4):1011-30. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26024063
  16. Smith MP. Diagnosis and management of bronchiectasis. CMAJ. 2017 Jun 19;189(24):E828-E835. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28630359 Free PMC Article
  17. NEJM Knowledge+ Question of the Week. April 16, 2019 https://knowledgeplus.nejm.org/question-of-week/561/
  18. Barker AF. Bronchiectasis. N Engl J Med 2002 May 3; 346:1383. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11986413 https://www.nejm.org/doi/full/10.1056/NEJMra012519
  19. Feldman C. Bronchiectasis: new approaches to diagnosis and management. Clin Chest Med. 2011 Sep;32(3):535-46. Review. PMID:21867821
  20. 20.0 20.1 20.2 20.3 Shoemark A et al. Characterization of eosinophilic bronchiectasis: A European multicohort study. Am J Respir Crit Care Med 2022 Apr 15; 205:894. PMID: https://www.ncbi.nlm.nih.gov/pubmed/35050830 https://www.atsjournals.org/doi/10.1164/rccm.202108-1889OC
    Singh D, Brightling C. Bronchiectasis, the latest eosinophilic airway disease: What about the microbiome? Am J Respir Crit Care Med 2022 Apr 15; 205:860. PMID: https://www.ncbi.nlm.nih.gov/pubmed/35213295 https://www.atsjournals.org/doi/10.1164/rccm.202201-0105ED
  21. NEJM Knowledge+ Question of the Week. Nov 8, 2022 https://knowledgeplus.nejm.org/question-of-week/233/
    Thompson GR, Young JAH. Aspergillus infections. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34644473 N Engl J Med 2021; 385:1496-1509 https://www.nejm.org/doi/full/10.1056/NEJMra2027424
    Patel G, Greenberger PA. Allergic bronchopulmonary aspergillosis. Allergy Asthma Proc 2019 Nov 1; 40:421-424. PMID: https://www.ncbi.nlm.nih.gov/pubmed/31690385
    Shah A, Panjabi C. Allergic bronchopulmonary aspergillosis: a perplexing clinical entity. Allergy Asthma Immunol Res 2016 Jul; 8:282-97. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27126721 PMCID: PMC4853505 Free PMC article
  22. O'Donnell AE. Bronchiectasis. Chest. 2008 Oct;134(4):815-823. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18842914 Review.
  23. 23.0 23.1 NEJM Knowledge+