peptide YY; PYY; PYY-I; peptide tyrosine tyrosine; contains: peptide YY(3-36), PYY-II (PYY)

Function

• inhibits food intake at the level of the hypothalamus
• effect lasts at least 12 hours
• no effect on fluid intake, gastric emptying, serum insulin, serum glucose or leptin levels
• inhibits exocrine pancreatic secretion
• has a vasoconstrictory action
• inhibitis jejunal & colonic peristalsis

Structure

belongs to the NPY family

Compartment

secreted

Alternative splicing

named isoforms=2

More general terms

• gastrointestinal hormone
• secreted peptide

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5697
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5697
• OMIM: https://mirror.omim.org/entry/600781
• UniProt: http://www.uniprot.org/uniprot/P10082.html