gastrin in serum

Reference interval

• 25-90 pg/mL
• < 180 pg/mL

Clinical significance

• gastrin levels follow a circadian pattern
• they are lowest at 0300-0700 hours & highest during the day or fluctuate in relation to meals
• see Increases:

Increases

• Zollinger Ellison syndrome
  • most have fasting levels > 500 pg/mL
  • 40% have fasting levels 100-500 pg/mL
• antral G-cell hyperplasia
• pyloric obstruction
• vagotomy without gastric resection
• retained antrum
• chronic atrophic gastritis
  • gastric carcinoid
• pernicious anemia
• chronic renal failure
• gastric carcinoma
• gastric ulcer
• pharmaceutical agents
  • oral amino acids
  • calcium carbonate
  • calcium chloride (IV)
  • catecholamines
  • cimetidine
  • coffee
  • insulin
  • proton pump inhibitors
    • omeprazole (Prilosec)
    • lansoprazole (Prevacid)
    • pantoprazole (Protonix)
    • rabeprazole (Aciphex)

Decreases

• antrectomy with vagotomy
• hypothyroidism
• pharmaceutical agents
  • atropine
  • secretin

Specimen

• patient preparation:
  • stop proton-pump inhibitors for 5 days prior to measurement of serum gastrin
• fasting
• serum
• freeze immediately, store at -70 degrees C

More general terms

• special chemistry test

More specific terms

• gastrin 14 residue fragment in serum
• gastrin 17 residue fragment in serum
• gastrin 34 residue fragment in serum
• gastrin in serum post secretin stimulation

Additional terms

• gastrin (GAST, GAS)