atrophic gastritis
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Etiology
- autoimmune disease: pernicious anemia
- persistent Helicobacter pylori infection
Pathology
- chronic inflammation of the gastric mucosa
- loss of gastric glandular cells & their eventual replacement by intestinal and fibrous tissue
- impaired secretion of hydrochloric acid, pepsin, & intrinsic factor
- vitamin B12 deficiency (pernicious anemia)
- iron deficiency anemia
- small intestinal bacterial overgrowth[3]
- gastric carcinoid
Laboratory
- serology for Helicobacter pylori
- rapid urease test from gastric biopsy tissue
- histology for H pylori
- anti-parietal cell antibody
- anti-intrinsic factor antibody
- serum vitamin B12
- serum gastrin (hypergastrinemia)
Diagnostic procedures
Complications
- increased risk of gastric cancer (adenocarcinoma)
Management
- treat Helicobacter pylori
- autoimmune atrophic gastritis
- vitamin B12 supplementation
- iron supplementation
- surveillance for gastric carcinoid[3]
More general terms
References
- ↑ Wikipedia: Atrophic gastritis http://en.wikipedia.org/wiki/Atrophic_gastritis
- ↑ Sepulveda AR and Katz J eMedicine: Atrophic Gastritis http://emedicine.medscape.com/article/176036-overview
- ↑ 3.0 3.1 3.2 Medical Knowledge Self Assessment Program (MKSAP) 18, 19. American College of Physicians, Philadelphia 2018, 2021
- ↑ Minalyan A, Benhammou JN, Artashesyan A, Lewis MS, Pisegna JR Autoimmune atrophic gastritis: current perspectives. Clin Exp Gastroenterol. 2017 Feb 7;10:19-27. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28223833 Free PMC Article