anti-parietal cell antibody (PCellAb)

Introduction

also see parietal cell antibody in serum

Etiology

• common in:
  • 95% of patients with pernicious anemia
    • 60% of patients with pernicious anemia also have intrinsic factor-blocking antibodies
  • up to 50% of patients atrophic gastritis without pernicious anemia
• 25-30% of patients with autoimmune thyroiditis
• lower frequency associated with:
  • Addison's disease
  • myasthenia gravis
  • juvenile diabetes mellitus
  • gastric ulcer
  • iron-deficiency anemia
  • Sjogren's syndrome

More general terms

• autoantibody

Additional terms

• parietal cell
• parietal cell antibody (PCellAb) in serum
• pernicious anemia; autoimmune gastritis