parietal cell antibody (PCellAb) in serum

Indications

• common in:
  • 95% of patients with pernicious anemia
    • 60% of patients with pernicious anemia also have intrinsic factor-blocking antibodies
  • up to 50% of patients atrophic gastritis without pernicious anemia
  • 25-30% of patients with autoimmune thyroiditis
• lower frequency associated with:
  • Addison's disease
  • myasthenia gravis
  • juvenile diabetes mellitus
  • gastric ulcer
  • iron-deficiency anemia
  • Sjogren's syndrome

Principle

• antibodies directed against microsomal components of gastric parietal cells.
• assay detects microsomal & cell-surface parietal cell autoantibodies

Methods

indirect immunofluorescence

Specimen

• serum
• stable for 12 months at -20 degrees C

Interferences

• no chemical interferences or in vivo effects known.

More general terms

• anti-parietal cell antibody (PCellAb) in body fluid

Additional terms

• anti-parietal cell antibody (PCellAb)
• parietal cell
• pernicious anemia; autoimmune gastritis