rabeprazole (Aciphex)

Introduction

Tradename: Aciphex. Generic approved nov 2013.

Indications

• duodenal ulcer
• gastroesophageal reflux disease (GERD)
  • pyrosis
• prevention of GI bleed due to hypersecretory conditions
  • Zollinger-Ellison syndrome
  • systemic mastocytosis
  • multiple endocrine neoplasia
• reflux esophagitis (treatment & maintenance)
• component of combination therapy for Helicobacter pylori

Dosage

20 mg PO QD

Tabs: 20 mg (delayed release).

Mechanism of action

• proton pump inhibitor
• interacts with sulfhydryl groups in proton pump
• inactive at neutral pH

More general terms

• proton pump inhibitor
• pyrrole

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60681
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5029