succinate dehydrogenase cytochrome b560 subunit (succinate dehydrogenase complex subunit C, succinate-ubiquinone oxidoreductase cytochrome B large subunit, CYBL, SDHC, CYB560, SDH3)

Function

• mono-heme cytochrome b
• may act as a mediator of low potential couples in an electron flow through cardiac complex 2
• component of mitochondrial electron transport complex 2 (succinate dehydrogenase) which transfers electrons from succinate to ubiquinone (coenzyme Q)
• carbohydrate metabolism; tricarboxylic acid cycle

Structure

belongs to the cytochrome b560 family

Compartment

mitochondrial inner membrane

Pathology

• defects in SDHC are the cause of autosomal dominant non-chromaffin paragangliomas type 3

Genetics

nuclear-encoded mitochondrial protein

More general terms

• cytochrome
• mitochondrial membrane protein

Component of

• succinate dehydrogenase (mitochondrial complex 2)

Database

• OMIM: https://mirror.omim.org/entry/602413
• OMIM: https://mirror.omim.org/entry/605373
• UniProt: http://www.uniprot.org/uniprot/Q99643.html