glucose-6-phosphate translocase; glucose-5-phosphate transporter; solute carrier family 37 member 4 (SLC37A4, G6PT, G6PT1, PRO0685)

Function

• transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum
• forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis & gluconeogenesis
• thus a role in homeostatic regulation of blood glucose levels

Structure

• belongs to the major facilitator superfamily, SLC37A family

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Expression

mostly expressed in liver & kidney

Pathology

• defects in SLC37A4 are the cause of glycogen storage disease type 1 (1B, 1C & 1D)

More general terms

• solute carrier family 37 (SLC37, SLC37A)
• major facilitator superfamily (MFS)
• transmembrane 10 protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2542
• OMIM: https://mirror.omim.org/entry/232220
• OMIM: https://mirror.omim.org/entry/232240
• OMIM: https://mirror.omim.org/entry/602671
• UniProt: http://www.uniprot.org/uniprot/O43826.html