glucose-6-phosphate translocase; glucose-5-phosphate transporter; solute carrier family 37 member 4 (SLC37A4, G6PT, G6PT1, PRO0685)
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Function
- transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum
- forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis & gluconeogenesis
- thus a role in homeostatic regulation of blood glucose levels
Structure
- belongs to the major facilitator superfamily, SLC37A family
Compartment
endoplasmic reticulum membrane
Alternative splicing
named isoforms=2
Expression
mostly expressed in liver & kidney
Pathology
- defects in SLC37A4 are the cause of glycogen storage disease type 1 (1B, 1C & 1D)
More general terms
- solute carrier family 37 (SLC37, SLC37A)
- major facilitator superfamily (MFS)
- transmembrane 10 protein
References
- ↑ UniProt http://www.uniprot.org/uniprot/O43826.html
- ↑ Web: Name=GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC37A4