glucose-6-phosphatase (G6Pase, G-6-Pase, G6PC, G6PT)

Function

• may act both as a hydrolase & a translocase
• key enzyme in homeostatic regulation of blood glucose levels
• gluconeogenesis & glycogenolysis; last step

D-glucose 6-phosphate + H2O <--> D-glucose + phosphate

Compartment

endoplasmic reticulum membrane

Pathology

• defects in G6PC are the cause of glycogen storage disease type 1A

More general terms

• phosphomonoesterase
• gluconeogenic enzyme
• glycoprotein
• membrane protein

Additional terms

• gluconeogenesis
• glycogen storage disease type-I (von Gierke type glycogen storage disease)

Database

• OMIM: https://mirror.omim.org/entry/232200
• UniProt: http://www.uniprot.org/uniprot/P35575.html