synaptic vesicular amine transporter; vesicular amine transporter 2; VAT2; monoamine transporter; solute carrier family 18 member 2 (SLC18A2, SVMT, VMAT2)
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Function
- role in the ATP-dependent vesicular transport of biogenic amine neurotransmitters
- pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, & histamine into synaptic vesicles
- requisite for vesicular amine storage prior to secretion via exocytosis
Structure
- belongs to the major facilitator superfamily vesicular transporter family
Compartment
cytoplasmic vesicle membrane
Pathology
- VMAT2 (SLC18A2) deficiency found is 8 children of a consanguineous Saudi Arabian family[3]
Pharmacology
- VMAT2 inhibitor valbenazine (Ingrezza) FDA-approved for treatment of tardive dyskinesia
- deutetrabenazine another VMAT2 inhibitor FDA-approved for treatment of Huntington's chorea
More general terms
- transmembrane 12 protein
- solute carrier family 18 (SLC18, SLC18A)
- glycoprotein
- phosphoprotein
- major facilitator superfamily (MFS)
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q05940.html
- ↑ Wikipedia; Note: vesicular monoamine transporter entry http://en.wikipedia.org/wiki/vesicular_monoamine_transporter
- ↑ 3.0 3.1 Rilstone JJ et al. Brain dopamine-serotonin vesicular transport disease and its treatment. N Engl J Med 2013