solute carrier family 17 member 5 (SLC17A5, sialin, Na+/sialic acid cotransporter, sodium phosphate cotransporter, AST, membrane glycoprotein HP59)

Function

• primary solute translocator for anionic substances
• free sialic acid transporter in the lysosomes (putative)

Structure

• belongs to the major facilitator superfamily Na+/anion cotransporter family

Compartment

lysosome membrane

Alternative splicing

named isoforms=2

Expression

• expressed in fetal lung & small intestine > fetal skin & muscle.
• in adults, expressed in placenta, kidney & pancreas

Pathology

• abundant in the endothelial cells from
  • ovarian cancer
  • colon cancer
  • breast cancer
  • lung cancer
• not detected in endothelial cells from the corresponding normal tissues
• defects in SLC17A5 are the cause of sialuria

More general terms

• transmembrane 12 protein
• solute carrier family 17 (SLC17, SLC17A)
• major facilitator superfamily (MFS)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2650
• OMIM: https://mirror.omim.org/entry/236750
• OMIM: https://mirror.omim.org/entry/269920
• OMIM: https://mirror.omim.org/entry/604322
• OMIM: https://mirror.omim.org/entry/604369
• UniProt: http://www.uniprot.org/uniprot/Q9NRA2.html