disrupted in renal carcinoma protein 2 (DIRC2)

Structure

• belongs to the major facilitator superfamily

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• expressed in proximal tubular cells of the kidney

Pathology

• chromosomal translocation t(2;3)(q35;q21) involving DIRC2 is found in familial renal cell carcinoma 1 (RCC1)

More general terms

• transmembrane 12 protein
• glycoprotein
• major facilitator superfamily (MFS)

Database

• OMIM: https://mirror.omim.org/entry/144700
• OMIM: https://mirror.omim.org/entry/602773
• UniProt: http://www.uniprot.org/uniprot/Q96SL1.html