cell division cycle-associated 7-like protein (protein JPO2, transcription factor RAM2, CDCA7L, HR1, JPO2 R1)
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Function
- role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity & gene expression by binding to the promoter
- role in apoptotic signaling pathways
- may act downstream of P38-kinase & BCL-2, but upstream of CASP3/caspase-3, CCND1/cyclin D1 & E2F1
- interacts with MYC & PSIP1
Compartment
- cytoplasm, nucleus
- associates with chromatin
- translocates from cytoplasm to nucleus under dexamethasone induction
Alternative splicing
named isoforms=2
Expression
Pathology
- overexpressed in medulloblastoma
- role in mediating the full transforming effect of MYC in medulloblastoma cells
- induced by MYC overexpression in neuroblastoma cell line
More general terms
- cell division cycle-associated protein 4 (CDCA)
- transcriptional silencer (transcriptional repressor)
- phosphoprotein