monoamine oxidase [MAO]-A

Function

• catalyzes oxidative deamination of biogenic & xenobiotic amines
• role in metabolism of neuroactive & vasoactive amines in the central nervous system & peripheral tissues
• MAOA preferentially oxidizes biogenic amines including 5-hydroxytryptamine (5-HT), norepinephrine & epinephrine

RCH(2)NH(2) + H2O + O2 <--> RCHO + NH3 + H2O2

Cofactor: FAD

Structure

• monomer, homodimer or heterodimer (containing two subunits of similar size)
• each subunit contains a covalently bound flavin
• enzymatically active as monomer
• belongs to the flavin monoamine oxidase family

Compartment

mitochondria outer membrane, cytoplasmic side

Expression

heart, liver, duodenum, blood vessels & kidney

Pathology

• defects in MAOA are the cause of Brunner syndrome

Laboratory

• MAOA gene upstream VNTR repeats

More general terms

• monoamine oxidase (MAO)

Database

• UniProt: http://www.uniprot.org/uniprot/P21397.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4128
• OMIM: https://mirror.omim.org/entry/309850
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4128