cell division cycle-associated protein 7 (protein JPO1) (CDCA7 JPO1)

Function

• role in MYC-mediated cell transformation
• induces anchorage-independent growth & clonogenicity in lymphoblastoid cells
• insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis
• role as transcriptional regulator
• activated by MYC & possibly E2F1

Compartment

nucleus

Alternative splicing

named isoforms=4

Expression

• ubiquitous with higher level in thymus & small intestine

Pathology

• expression correlated with MYC expression in lymphoblastoid, lymphoma & breast cancer cell lines
• overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) & in chronic myelogenous leukemia (CML) blast crisis

More general terms

• cell division cycle-associated protein 4 (CDCA)
• transcription factor (TF)

Additional terms

• cell division cycle-associated 7-like protein (protein JPO2, transcription factor RAM2, CDCA7L, HR1, JPO2 R1)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BWT1.html