disheveled-associated activator of morphogenesis 1 (DAAM1, KIAA0666)
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Function
- binds to disheveled (Dvl) & Rho
- mediates Wnt-induced Dvl-Rho complex formation
- role as a scaffolding protein to recruit Rho-GDP & Rho-GEF, thereby, enhancing Rho-GTP formation
Structure
- belongs to the formin homology family
- contains 1 DAD domain (diaphanous autoregulatory domain)
- contains 1 FH1 domain (formin homology 1 domain)
- contains 1 FH2 domain (formin homology 2 domain)
- contains 1 GBD/FH3 domain (Rho GTPase-binding/formin homology 3 domain)
Alternative splicing
named isoforms=3
Expression
expressed in all tissues examined