disheveled-associated activator of morphogenesis 1 (DAAM1, KIAA0666)

Function

• binds to disheveled (Dvl) & Rho
• mediates Wnt-induced Dvl-Rho complex formation
• role as a scaffolding protein to recruit Rho-GDP & Rho-GEF, thereby, enhancing Rho-GTP formation

Structure

• belongs to the formin homology family
• contains 1 DAD domain (diaphanous autoregulatory domain)
  • contains 1 FH1 domain (formin homology 1 domain)
  • contains 1 FH2 domain (formin homology 2 domain)
  • contains 1 GBD/FH3 domain (Rho GTPase-binding/formin homology 3 domain)

Alternative splicing

named isoforms=3

Expression

expressed in all tissues examined

More general terms

• scaffold protein

Database

• OMIM: https://mirror.omim.org/entry/606626
• UniProt: http://www.uniprot.org/uniprot/Q9Y4D1.html