hepatocyte growth factor; hepatopoietin-A; scatter factor; SF (HGF, HPTA)

Function

• potent mitogen for mature parenchymal hepatocyte cells
• seems to be an hepatotrophic factor
• acts as growth factor for a broad spectrum of tissues & cell types
• stimulates the formation of focal adhesions.
• has no detectable protease activity

Structure

• dimer of an alpha chain & a beta chain linked by a disulfide bond
• belongs to the peptidase S1 family, plasminogen subfamily
• contains 4 kringle domains
• contains 1 PAN domain
• contains 1 peptidase S1 domain

Alternative splicing

named isoforms=6

Pathology

• defects in HGF are the cause of autosomal recessive deafness type 39

Laboratory

• hepatocyte growth factor in serum

More general terms

• secreted protein
• glycoprotein

Additional terms

• hepatocyte growth factor activator (HGFAC)
• hepatocyte growth factor receptor; HGF receptor; scatter factor receptor; SF receptor; HGF/SF receptor; Met proto-oncogene tyrosine kinase; c-Met (MET)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3082
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3082
• OMIM: https://mirror.omim.org/entry/142409
• OMIM: https://mirror.omim.org/entry/608265
• UniProt: http://www.uniprot.org/uniprot/P14210.html