hepatocyte growth factor receptor; HGF receptor; scatter factor receptor; SF receptor; HGF/SF receptor; Met proto-oncogene tyrosine kinase; c-Met (MET)
Jump to navigation
Jump to search
Function
- receptor for hepatocyte growth factor & scatter factor
- has a tyrosine-protein kinase activity
- binds PLXNB1 & GRB2
- interacts with SPSB1, SPSB2 & SPSB4 (putative)
- interacts with INPP5D/SHIP1
- when phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2
- interacts with RANBP9 & RANBP10, as well as SPSB1, SPSB2, SPSB3 & SPSB4
- SPSB1 binding occurs in the presence & in the absence of HGF, however HGF treatment has a positive effect on this interaction
Structure
- heterodimer formed of an alpha chain (50 kD) & a beta chain (145 kD) which are disulfide linked
- the kinase domain is involved in SPSB1 binding
- belongs to the protein kinase superfamily, Tyr protein kinase family
- contains 3 IPT/TIG domains
- contains 1 protein kinase domain
- contains 1 Sema domain
Compartment
membrane
Alternative splicing
named isoforms=2
Pathology
- activation of MET after rearrangement with the TPR gene produces an oncogenic protein
- defects in MET may be associated with gastric cancer
- defects in MET are a cause of
- genetic variations in MET may be associated with susceptibility to autism type 1B
- c-Met is present in greater abundance on the cell surface of colorectal hyperplastic polyps & colorectal adenomas than on normal colorectal mucosa[6]
Pharmacology
- probe consisting of a peptide that binds to c-Met is attached to a fluorescent dye is used in fluorescence-guided colonoscopy[6]
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P08581.html
- ↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/METID131.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=MET
- ↑ Wikipedia; C-MET entry http://en.wikipedia.org/wiki/C-MET
- ↑ Giordano S, Ponzetto C, Di Renzo MF, Cooper CS, Comoglio PM. Tyrosine kinase receptor indistinguishable from the c-met protein Nature. 1989 May 11;339(6220):155-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2541345
- ↑ 6.0 6.1 6.2 Burggraaf J et al. Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met. Nat Med 2015 Aug; 21:955 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26168295
Database
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4233
- OMIM: https://mirror.omim.org/entry/114550
- OMIM: https://mirror.omim.org/entry/164860
- OMIM: https://mirror.omim.org/entry/605074
- OMIM: https://mirror.omim.org/entry/608636
- UniProt: http://www.uniprot.org/uniprot/P08581.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4233