Ran-binding protein 10 (RanBP10, RANBP10, KIAA1464)

Function

• may act as an adapter protein to couple membrane receptors to intracellular signaling pathways
• in contrast to RANBP9, does not interact with Sos & does not activate the Ras pathway
• interacts with RAN
• interacts with the HGF receptor MET

Structure

• SPRY domain mediates the interaction with MET
• belongs to the RANBP9/10 family
• contains 1 B30.2/SPRY domain
• contains 1 CTLH domain
• contains 1 LisH domain

Expression

• broadly expressed, with highest levels in skeletal muscle

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6VN20.html