fluorescence-guided colonoscopy
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Clinical significance
- fluorescence-guided colonoscopy detects flat & nonpolypoid colorectal adenomas better than standard colonoscopy
Procedure
- probe consisting of a peptide that binds to c-Met is attached to a fluorescent dye
- the peptide-fluorescent dye conjugate is injected IV ~ 3 hours prior to colonoscopy
- c-Met is present in greater abundance on the cell surface of colorectal hyperplastic polyps & colorectal adenomas than on normal colorectal mucosa
- somehow the peptide-fluorescent dye conjugate attaches to c-Met on the colorectal mucosa
- near-infrared fluorescent light is used to identify the the attached peptide-fluorescent dye conjugate
- normal white light is also used as in standard colonoscopy
More general terms
References
- ↑ Burggraaf J et al. Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met. Nat Med 2015 Aug; 21:955 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26168295