phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (SH2 domain-containing inositol-5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1, inositol polyphosphate-5-phosphatase of 145 kD, SIP-145, p150Ship, hp51CN, INPP5D, SHIP, SHIP1)

From Aaushi
Jump to navigation Jump to search

Function

phosphatidylinositol 3,4,5-trisphosphate + H2O <--> phosphatidylinositol 3,4-bisphosphate + phosphate

Structure

Compartment

Alternative splicing

named isoforms=3

Expression

  • specifically expressed in immune & hematopoietic cells
  • expressed in bone marrow & blood cells
  • levels vary considerably within this compartment
  • present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells
  • present in the majority of T-cells, while it is present in a minority of B-cells (at protein level)

More general terms

References

Database