inositol-1,2,3,4,5,6-hexaphosphate (IP6, phytic acid)
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Introduction
Inositol-1,3,4,5,6-pentaphosphate & inositol hexaphosphate [IP6] comprise the bulk of the inositol phosphate content of mammalian cells.
Function
- mRNA export
- nonhomologous end-joining
- endocytosis
- ion channel regulation
- protects cells from TNF-alpha-induced apoptosis
- may have anti-carcinogenic properties [2-6]
Notes
More general terms
References
- ↑ Menniti FS, Oliver KG, Putney JW Jr, Shears SB. Inositol phosphates and cell signaling: new views of InsP5 and InsP6. Trends Biochem Sci. 1993 Feb;18(2):53-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8387704
- ↑ Somasundar P, Riggs DR, Jackson BJ, Cunningham C, Vona-Davis L, McFadden DW. Inositol Hexaphosphate (IP6): A Novel Treatment for Pancreatic Cancer(1). J Surg Res. 2005 Jun 15;126(2):199-203. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15919420
Agarwal C, Dhanalakshmi S, Singh RP, Agarwal R. Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells. Neoplasia. 2004 Sep-Oct;6(5):646-59. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15548374 - ↑ Vucenik I, Ramakrishna G, Tantivejkul K, Anderson LM, Ramljak D. Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation. Breast Cancer Res Treat. 2005 May;91(1):35-45. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15868430
- ↑ Vucenik I, Passaniti A, Vitolo MI, Tantivejkul K, Eggleton P, Shamsuddin AM. Anti-angiogenic activity of inositol hexaphosphate (IP6). Carcinogenesis. 2004 Nov;25(11):2115-23. Epub 2004 Aug 5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15297368
- ↑ Tantivejkul K, Vucenik I, Shamsuddin AM. Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis: I. In vitro studies of adhesion, migration and invasion of MDA-MB 231 human breast cancer cells. Anticancer Res. 2003 Sep-Oct;23(5A):3671-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14666663
Tantivejkul K, Vucenik I, Shamsuddin AM. Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis: II. Effects on integrins and focal adhesions. Anticancer Res. 2003 Sep-Oct;23(5A):3681-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14666664 - ↑ Vucenik I, Shamsuddin AM. Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. J Nutr. 2003 Nov;133(11 Suppl 1):3778S-3784S. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14608114
- ↑ 7.0 7.1 InoCell http://www.inocell.com/index.html
- ↑ UniProt http://www.uniprot.org/uniprot/Q9H8X2.html
Database
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=890
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5351582
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=498066
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=26626
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=24495
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=19234