signaling lymphocytic activation molecule; CDw150; IPO-3; CD150 (SLAMF1, SLAM)

Function

• high-affinity self-ligand
• role in bidirectional T- cell to B-cell stimulation
• SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells
• two modes of SLAM signaling are likely to exist
  • one in which the inhibitor SH2D1A acts as a negative regulator
  • another in which protein-tyrosine phosphatase 2C (PTPN11)- dependent signal transduction operates
• phosphorylated by FYN
• interacts (via cytoplasmic domain) with SH2D1A, & with PTPN11
• interacts with INPP5D/SHIP1
• binds to Measles virus H protein & acts as a receptor for this virus

Structure

• the most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A & does not need to be phosphorylated on Tyr
• contains 1 Ig-like C2-type domain
• contains 1 Ig-like V-type domain

Compartment

• cell membrane; single-pass type 1 membrane protein
• present on the surface of B-cells & T-cells

Alternative splicing

named isoforms=3

Expression

• constitutively expressed on
  • peripheral blood memory T-cells (CD45RO positive subpopulation of T cells)
  • T-cell clones
  • immature thymocytes
  • some B cells
  • dendritic cells
  • endothelium
• rapidly induced on naive T-cells after activation

More general terms

• CD antigen
• SLAM family member protein
• immunoglobulin superfamily protein
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6504
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6504
• OMIM: https://mirror.omim.org/entry/603492
• UniProt: http://www.uniprot.org/uniprot/Q13291.html