docking protein 3; downstream of tyrosine kinase 3 (DOK3)

Introduction

Docking proteins interact with receptor tyrosine kinases & mediate particular biological responses.

Function

• negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1
• may modulate ABL1 function
• constitutively Tyr-phosphorylated (putative)
• on IL2 stimulation, phosphorylated on C-terminal Tyr possibly by Src kinases
• can also be phosphorylated by ABL1 kinase (putative)
• on Tyr phosphorylation, interacts with CSK & INPP5D/SHIP1 via their SH2 domains
• both Tyr-381 & Tyr-398 are required for interaction with INPP5D
• only Tyr-381 is required for interaction with CSK
• binds ABL1 through the PTB domain (kinase-dependent)
• does not interact with RasGAP

Structure

• PTB domain mediates receptor interaction (putative)
• belongs to the DOK family, type A subfamily
• contains 1 IRS-type PTB domain
• contains 1 PH domain

Compartment

• cytoplasm (putative)
• cell membrane, cytoplasmic side (putative)

Alternative splicing

named isoforms=4

Expression

expressed in spleen

More general terms

• phosphoprotein
• nuclear protein
• docking protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79930
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79930
• OMIM: https://mirror.omim.org/entry/611435
• UniProt: http://www.uniprot.org/uniprot/Q7L591.html