hepatocyte growth factor activator (HGFAC)

Function

• activates hepatocyte growth factor by converting it from a single chain to a heterodimeric form

Structure

• heterodimer of a short chain & a long chain linked by a disulfide bond
• belongs to the peptidase S1 family
• contains 2 EGF-like domains
• contains 1 fibronectin type-I domain
• contains 1 fibronectin type-II domain
• contains 1 kringle domain
• contains 1 peptidase S1 domain

Compartment

• secreted
• secreted as an inactive single-chain precursor & is then activated to a heterodimeric form

Expression

liver

Notes

uncertain whether Met-1 is the initiator

More general terms

• serine protease
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q04756.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3083
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3083
• OMIM: https://mirror.omim.org/entry/604552