retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; GMP-PDE gamma (PDE6G, PDEG)

Function

• role in processes of transmission & amplification of the visual signal
• cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods & cones
• component of hetrotetramer composed of 2 catalytic chains (PDE6A, PDE6B), an inhibitory chain (PDE6G) & PDE6D

guanosine 3',5'-cyclic phosphate + H2O =guanosine 5'-phosphate

Structure

• belongs to the rod/cone cGMP-PDE gamma subunit family

Pathology

• defects in PDE6G are the cause of retinitis pigmentosa type 57

More general terms

• protein subunit
• phosphodiesterase 6

Component of

• photoreceptor cGMP phosphodiesterase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5148
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5148
• OMIM: https://mirror.omim.org/entry/180073
• OMIM: https://mirror.omim.org/entry/613582
• UniProt: http://www.uniprot.org/uniprot/P18545.html