Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; GMP-PDE alpha; PDE V-B1 (PDE6A, PDEA)

Function

• this protein participates in processes of transmission & amplification of the visual signal
• component of hetrotetramer composed of 2 catalytic chains (PDE6A, PDE6B), an inhibitory chain (PDE6G) & PDE6D

guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

Cofactor:

• binds 2 divalent metal cations per subunit
• site 1 may preferentially bind Zn+2
• site 2 has a preference for Mg+2 &/or Mn+2 (putative)

Structure

• belongs to the cyclic nucleotide phosphodiesterase family
• contains 2 GAF domains

Compartment

• cell membrane; lipid-anchor; cytoplasmic side (putative)

Pathology

• defects in PDE6A are a cause of retinitis pigmentosa, autosomal recessive

More general terms

• protein subunit
• phosphodiesterase 6
• prenyl protein

Component of

• photoreceptor cGMP phosphodiesterase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5145
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5145
• OMIM: https://mirror.omim.org/entry/180071
• OMIM: https://mirror.omim.org/entry/268000
• UniProt: http://www.uniprot.org/uniprot/P16499.html