retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; GMP-PDE delta; protein p17 (PDE6D, PDED)

Function

• acts as a GTP specific dissociation inhibitor (GDI)
• increases the affinity of ARL3 for GTP by several orders of magnitude & does so by decreasing the nucleotide dissociation rate
• stabilizes Arl3-GTP by decreasing the nucleotide dissociation (putative)
• interacts with ARL2, ARL3, & RPGR
• component of hetrotetramer composed of 2 catalytic chains (PDE6A, PDE6B), an inhibitory chain (PDE6G) & PDE6D
• interacts with ARL3; the interaction occurs specifically with the GTP-bound form of ARL3 (putative)
• interacts with HRAS & RPGR

Structure

belongs to the PDE6D/unc-119 family

Expression

retina

More general terms

• phosphodiesterase 6
• GDP dissociation inhibitor (GDI)

Component of

• photoreceptor cGMP phosphodiesterase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5147
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5147
• OMIM: https://mirror.omim.org/entry/602676
• UniProt: http://www.uniprot.org/uniprot/O43924.html