ADP-ribosylation factor-like protein 2 (ARL2)

Function

• GTP-binding protein
• component of a regulated secretory pathway involved in Ca+2-dependent release of acetylcholine
• regulates formation of new microtubules
• required for normal progress through the cell cycle
• interacts with SCOC & ELMOD2
• GTP-bound form interacts with ARL2BP

Structure

belongs to the small GTPase superfamily, Arf family

Compartment

centrosome

Pathology

• does not act as an allosteric activator of the cholera toxin catalytic subunit

More general terms

• ADP-ribosylation factor-like protein (ARL)

Database

• UniProt: http://www.uniprot.org/uniprot/P36404.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=402
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:402
• OMIM: https://mirror.omim.org/entry/601175