A-kinase anchor protein 9; AKAP-9; A-kinase anchor protein 350 kD; AKAP 350; hgAKAP 350; A-kinase anchor protein 450 kD; AKAP 450; AKAP 120-like protein; centrosome- & Golgi-localized PKN-associated protein; CG-NAP; protein hyperion; protein kinase A-anchoring protein 9; PRKA9; protein yotiao (AKAP9 AKAP350 AKAP450 KIAA0803)

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Function

binds to protein kinase A type II regulatory subunits
scaffolding protein that assembles several protein kinases & phosphatases on the centrosome & Golgi apparatus
may be required to maintain the integrity of the Golgi
isoform 4 is associated with the N-methyl-D-aspartate receptor & is specifically found in the neuromuscular junction as well as in neuronal synapses, suggesting a role in organization of postsynaptic specializations
phosphorylated upon DNA damage, probably by ATM or ATR
interacts with the regulatory region of protein kinase N (PKN), protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1) & the immature non-phosphorylated form of PKC epsilon
interacts with CIP4 & FNBP1
interacts with chloride intracellular channel proteins CLIC1, CLIC4 & CLIC5

PKA RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the PKA-R-subunit dimer