programmed cell death 6-interacting protein; PDCD6-interacting protein; ALG-2 interacting protein 1; Hp95 (PDCD6IP, AIP1, KIAA1375)

Introduction

Class E VPS protein

Function

• concentration & sorting of cargo proteins in the multivesicular body pathway as (component of ESCRT1)
• apoptosis
• cell proliferation
• interacts with ESCRT3 components CHMP4A, CHMP4B & CHMP4C
• interacts with TSG101

Pathology

• interacts with viral proteins HIV-1 p6 & EIAV p9
• the HIV-1 virus hijacks PDCD6IP for viral exocytosis & budding, via its interaction with HIV-1 p6 protein

More general terms

• other protein

Additional terms

• programmed cell death protein 6; apoptosis-linked gene 2 protein; Ca+2-binding protein ALG-2 (PDCD6, ALG2)

Component of

• endosomal sorting complex required for transport-1 (ESCRT1)

Database

• OMIM: https://mirror.omim.org/entry/608074
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10015
• UniProt: http://www.uniprot.org/uniprot/Q8WUM4.html