endosomal sorting complex required for transport-3 (ESCRT3)
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Function
- multivesicular body pathway
- formation & sorting of endosomal cargo proteins into MVBs
- chromosome condensation (putative)[2]
- stable cell cycle progression[2]
- PcG gene silencing[2]
- recruits ESCRT2 complex
Pathology
- HIV-1 virus takes advantage of ESCRT3 for budding & exocytic cargos of viral proteins