polycomb complex protein BMI-1; polycomb group RING finger protein 4; RING finger protein 51 (BMI1, PCGF4, RNF51)

Function

• component of polycomb group (PcG) multiprotein PRC1 complex
• component of E3 ubiquitin ligase complex or polycomb repressive complex 1-like at least composed of PHC2, BMI1, RING1 & RNF2
• part of a complex consisting of BMI1, CUL3 & SPOP
• interacts with SPOP
• interacts with E4F1

Structure

contains 1 RING-type Zn+2 finger

Compartment

nucleus. cytoplasm

Pathology

• cooperates with the MYC oncogene to produce B-cell lymphomas

More general terms

• DNA-binding protein
• proto oncogene protein
• phosphoprotein
• ring finger protein

Component of

• Polycomb group multiprotein PRC1 complex (PcG PRC1 complex, hPRC-H, PcG repressive complex 1)

Database

• UniProt: http://www.uniprot.org/uniprot/P35226.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=648
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:648
• OMIM: https://mirror.omim.org/entry/164831