speckle-type POZ protein (SPOP)

Function

• inhibits IPF1/PDX1 transactivation of promoters, including insulin gene promoter
• recruits transcription repressor complex (putative)
• ubiquitination of both PCGF4 & H2AFY, in association with CUL3
• ubiquitin conjugation, 3rd step
• component of complex consisting of PCGF4, CUL3 & SPOP
• component of complex consisting of H2AFY, CUL3 & SPOP
• interacts with H2AFY, IPF1/PDX1 & PCGF4
  • MATH domain interacts with H2AFY & PCGF4

Structure

• belongs to the Tdpoz family
• contains 1 BTB domain (POZ domain)
• contains 1 MATH domain

Compartment

nucleus

Expression

widely expressed

Pathology

• antigen recognized by serum from scleroderma patient

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/602650
• UniProt: http://www.uniprot.org/uniprot/O43791.html