polyhomeotic-like protein 2 (hPH2, early development regulatory protein 2, PHC2, EDR2, PH2)

Function

• component of PRC1 complex
• interacts with N-terminal region of SP1 transcription factor & with MAPKAPK2

Structure

• HD1 motif interacts with SAM domain of PHC1
• contains 1 FCS-type zinc finger contains 1 SAM domain (sterile alpha motif)

Compartment

nucleus

Alternative splicing

named isoforms=3

More general terms

• nuclear protein
• protein subunit
• phosphoprotein
• zinc finger protein

Component of

• Polycomb group multiprotein PRC1 complex (PcG PRC1 complex, hPRC-H, PcG repressive complex 1)

Database

• OMIM: https://mirror.omim.org/entry/602979
• UniProt: http://www.uniprot.org/uniprot/Q8IXK0.html