MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2, MK2, MAPKAPK2)

Function

• its physiological substrate seems to be HSP27/HSP25
• in vitro can phosphorylate glycogen synthase at Ser-7' & tyrosine hydroxylase (on Ser-19 & Ser-40)
• phosphorylates Ser in the peptide sequence, hyd-X-R-X(2)-S, where hyd is a large hydrophobic residue
• mediates both ERK & p38 MAPK/MAPK14 dependent neutrophil responses
• participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils
• plays a role in phagocytosis-induced respiratory burst activity
• interacts with PHC2
• seems to be activated by two distinct pathways:
  • stimulation of p42/p44 MAPK by growth factors
  • triggered by stress & heat shock, dependent on activation of MPK2 & upstream MAPKK/MAPKKK
• phosphorylated & activated by MAP kinase

ATP + a protein <--> ADP + a phosphoprotein

Structure

• belongs to the protein kinase superfamily, Ser/Thr protein kinase family
• contains 1 protein kinase domain

Alternative splicing

named isoforms=2

Expression

expressed in all tissues examined

More general terms

• MAP kinase-activated protein kinase

Database

• OMIM: https://mirror.omim.org/entry/602006
• UniProt: http://www.uniprot.org/uniprot/P49137.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9261