heat shock protein beta-1; HspB1; heat shock 27 kD protein; HSP 27; stress-responsive protein 27; SRP27; estrogen-regulated 24 kD protein; 28 kD heat shock protein (HSPB1, HSP27, HSP28)
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Introduction
A member of the hsp20 or low molecular weight hsp family.
Function
- role in stress resistance & actin organization
- phosphorylated in MCF-7 cells on exposure to
- protein kinase C activators
- heat shock
- interacts with hspB8, HSPBAP1, CRYAB
- associates with:
- induced by
- heat shock
- estrogen stimulation
Structure
- belongs to the small heat shock protein (HSP20) family
Compartment
- cytoplasm, nucleus, spindle
- cytoplasmic in interphase cells
- colocalizes with mitotic spindles in mitotic cells
- translocates to the nucleus during heat shock
Expression
- detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood (serum) & cerebrospinal fluid
- highest levels are found in the heart & in tissues composed of striated & smooth muscle
- expressed in response to environmental stresses such as heat shock, or estrogen stimulation in MCF-7 cells
Pathology
- mutations associated with:
- Charcot-Marie-Tooth disease type 2F (CMT2F)
- distal hereditary motor neuropathy (dHMN)
More general terms
References
- ↑ Martinus RD Role of chaperones in the biogenesis and maintenance of the mitochondrion. FASEB J 9:371 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7896006
- ↑ Prosite :accession PS01031
- ↑ UniProt http://www.uniprot.org/uniprot/P04792.html
- ↑ Inherited peripheral neuropathies mutation db http://www.molgen.ua.ac.be/CMTmutations/
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=HSPB1
- ↑ NIEHS SNPs http://egp.gs.washington.edu/data/hspb1/
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3315
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3315
- OMIM: https://mirror.omim.org/entry/602195
- OMIM: https://mirror.omim.org/entry/606595
- OMIM: https://mirror.omim.org/entry/608634
- UniProt: http://www.uniprot.org/uniprot/P04792.html