alpha-crystallin C chain; heat shock protein beta-8; HspB8; E2-induced gene 1 protein; protein kinase H11; small stress protein-like protein HSP22 (HSPB8, CRYAC, E2IG1, HSP22, PP1629)
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Function
Structure
- monmer
- belongs to the small heat shock protein (HSP20) family
Compartment
- cytoplasm, nucleus
- translocates to nuclear foci during heat shock
Expression
- predominantly expressed in skeletal muscle & heart
- induced by 17-beta-estradiol
Pathology
- defects in HSPB8 are the cause of
Notes
- reported to be Mn+2 dependent serine/threonine kinase
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9UJY1.html
- ↑ Inherited peripheral neuropathies mutation db http://www.molgen.ua.ac.be/CMTmutations/
- ↑ GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/HSPB8
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26353
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26353
- OMIM: https://mirror.omim.org/entry/158590
- OMIM: https://mirror.omim.org/entry/608014
- OMIM: https://mirror.omim.org/entry/608673
- UniProt: http://www.uniprot.org/uniprot/Q9UJY1.html