HSPB1-associated protein 1 (27 kD heat shock protein-associated protein 1, protein associated with small stress protein 1, HSPBAP1, PASS1)

Function

• role in cellular stress response
• interacts with CRYAB & HSPB

Structure

contains 1 JmjC domain

Compartment

cytoplasm

Alternative splicing

named isoforms=3

Expression

widely expressed Patholology:

• chromosomal translocation t(2;3)(q35;q21) involving HSPBAP1 with the putative pseudogene DIRC3 is found in familial renal cell carcinoma 1
  • results in hybrid mRNA encoding a truncated HSPBAP1 lacking 1st 36 amino acids

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/144700
• OMIM: https://mirror.omim.org/entry/608263
• UniProt: http://www.uniprot.org/uniprot/Q96EW2.html