programmed cell death protein 6; apoptosis-linked gene 2 protein; Ca+2-binding protein ALG-2 (PDCD6, ALG2)

Function

• Ca+2-binding protein required for T-cell receptor-, Fas-, & glucocorticoid-induced cell death
• may mediate Ca+2-regulated signals along the death pathway (putative)
• Ca+2-dependent adapter necessary for the association between PDCD6IP & TSG101
• self-associates (putative), homodimer
• interacts with PEF1
• interacts with RBM22
• interacts with PLSCR4, ANXA7 & TSG101
• interacts with SEC31A, PDCD6IP, & the N-termini of ANXA11 & PLSCR3 (Ca+2-dependent)

Structure

contains 5 EF-hand domains

Compartment

• nuclear membrane; peripheral membrane
• endoplasmic reticulum membrane
• interaction with RBM22 induces relocalization from the cytoplasm to the nucleus

More general terms

• Ca+2 binding protein
• nuclear protein

Additional terms

• apoptosis
• programmed cell death 6-interacting protein; PDCD6-interacting protein; ALG-2 interacting protein 1; Hp95 (PDCD6IP, AIP1, KIAA1375)
• programmed cell death protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10016
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10016
• OMIM: https://mirror.omim.org/entry/601057
• UniProt: http://www.uniprot.org/uniprot/O75340.html