phospholipid scramblase 4; PL scramblase 4; Ca+2-dependent phospholipid scramblase 4; cell growth-inhibiting gene 43 protein; TRA1 (PLSCR4)

Function

• may facilitate ATP-independent bidirectional transbilayer migration of phospholipids upon binding Ca+2, resulting in a loss of phospholipid asymmetry in the plasma membrane
• role in the initiation of fibrin clot formation
• role in activation of mast cells
• role in recognition of apoptotic & injured cells by the reticuloendothelial system
• interacts with PDCD6

Cofactor: Ca+2 (putative)

Structure

• belongs to the phospholipid scramblase family

Compartment

• membrane; single-pass type 2 membrane protein (putative)

Expression

• expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine & colon
• not expressed in peripheral blood lymphocytes

More general terms

• phospholipid scramblase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57088
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57088
• OMIM: https://mirror.omim.org/entry/607612
• UniProt: http://www.uniprot.org/uniprot/Q9NRQ2.html